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Do enzymes only ever catalyse chemical reactions involving covalent bonds?

April 26, 2017bonds catalyse chemical reactions covalent enzymes involving

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Do enzymes only ever catalyse chemical reactions involving covalent bonds?

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A colleague and I were wondering about this. Enzymes are biological catalysts that increase the rate of chemical reactions within the body. I’ve always assumed that these reactions are always covalent, but my colleague was wondering if this is absolutely always the case. I’m pretty sure that interactions with hydrogen bonds aren’t chemical reactions, and that ionic bonding doesn’t really happen in organic chemistry.