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Do commonly used oral antihypertensives alter fetal or neonatal heart rate characteristics?

April 26, 2017antihypertensives characteristics Commonly Fetal heart neonatal oral rate Used

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Do commonly used oral antihypertensives alter fetal or neonatal heart rate characteristics?

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Author(s): Waterman EJ, Magee LA, Lim KI, Skoll A, Rurak D, von Dadelszen P Affiliation(s): Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Publication date & source: 2004, Hypertens Pregnancy., 23(2):155-69. Publication type: Review OBJECTIVE: To examine fetal (FHR) and neonatal heart rate patterns following use of common oral antihypertensives in pregnancy. METHODS: A systematic review of randomized controlled trials (RCTs), observational studies (N >/= 6 women), and animal studies. Data were abstracted (two reviewers) to determine relative risk (RR) (or risk difference (RD) for low event rates) and 95% CI. RESULTS: Eighteen RCTs (1858 women), one controlled observational study (N = 22), and seven case series (N = 117) were reviewed. Most hypertension was pregnancy-induced (N = 14 studies). The FHR was assessed by cardiotocogram (CTG) (N = 17 studies (visual interpretation); 1 study (computerized CTG), or umbilical artery velocimetry (N = 4).