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Do Cerebral Blood Volume and Contrast Transfer Coefficient Predict Prognosis in Human Glioma?

April 26, 2017blood cerebral coefficient contrast glioma Human predict Prognosis transfer volume

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Do Cerebral Blood Volume and Contrast Transfer Coefficient Predict Prognosis in Human Glioma?

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INTRODUCTION: Noninvasive measurements of cerebral blood volume (CBV) and contrast transfer coefficient (Ktrans) have potential benefits in the diagnosis and therapeutic management of adult glioma. This study examines the relationship between CBV, Ktrans, and overall survival. METHODS AND MATERIALS: Twenty-seven adult patients with glioma underwent T1-weighted dynamic contrast-enhanced MR imaging, and parametric maps of CBV and Ktrans were calculated. The relationship of histologic grade, CBV, Ktrans, age, sex, surgical resection, and use of adjuvant therapy to survival were analyzed by using the logrank method and Cox regression analysis. The Kaplan-Meier method for displaying survival curves was used. The relationship of factors such as comorbidity, elevated intracranial pressure, size of nonenhancing tumor, and peritumoral edema were not considered. RESULTS: Both CBV (P < .01) and Ktrans (P < .01) show a significant relationship to histologic grade. CBV (P = .004), Ktrans (P = .008)