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Do arterial effects of antihypertensive drugs depend on subjects serum cholesterol?

April 26, 2017antihypertensive Arterial cholesterol depend drugs prescription drug serum Subject

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Do arterial effects of antihypertensive drugs depend on subjects serum cholesterol?

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Author(s): Megnien JL, Simon A, Mikaberidze E, Denarie N, Chironi G, Barra J, Armentano R, Levenson J Affiliation(s): Centre of Preventive Cardiovascular Medicine and CRI INSERM, Hopital Broussais, Paris, France. Publication date & source: 2001-10, J Cardiovasc Pharmacol., 38(4):520-8. Publication type: Clinical Trial; Randomized Controlled Trial Effects of antihypertensive treatment on large arteries may be influenced by the type of drug and concomitant risk factors such as blood cholesterol. To explore these possibilities we investigated the common carotid artery of 20 subjects with low cholesterol and 19 subjects with high cholesterol, all with essential hypertension, randomly allocated to 3 months of treatment with nitrendipine (20 mg/d) or trandolapril (2 mg/d). Carotid parameters were determined by recording instantaneous pressure (applanation tonometry) and diameter (echotracking device) and by modeling the pressure-diameter loop to obtain the Peterson modulus, stiffness index,