Do any drugs currently exist to restore succinate dehydrogenase function?
Not really. However, we may have other strategies to manipulate mitochondrial function in relationship to tumorigenesis. 3. How about drugs to inhibit hypoxia-inducible factor 1 alpha? Would those drugs potentially be useful? Yes, both the SDH pathway and the KIT pathway converge on hypoxia-inducible factor 1 alpha (HIF-1a); therefore, HIF-1a inhibitors might be clinically helpful. 4. At the most basic level, what is the function of succinate dehydrogenase (SDH) in normal cellular metabolism? SDH is required in the Krebs cycle (also called the citric acid cycle), the mechanism normal cells use to obtain energy from glucose through chemical reactions involving oxygen. This process is sometimes called “cellular respiration.” For a more detailed explanation see this link: http://incolor.inebraska.com/mcanaday/main.htm 5. What is pseudo-hypoxia and how does it promote cancer? Tumors cannot grow large without developing new blood vessels to supply them with oxygen and glucose. If the cell i
