Do all antidepressants help OCD symptoms?
In clinical studies, only the SRIs have shown to be effective for OCD. Some commonly used antidepressants have little or no effect on serotonin in the brain. As such, they have not been shown to be helpful for OCD symptoms. Good anti-depressants, such as imipramine (Tofranil), amitriptyline (Elavil), or buproprion (Wellbutrin), only rarely improve OCD symptoms.