Did the UNLOAD study diurese the standard care group to the fullest possible extent?
4 A: “Aggressive diureses” was ensured by requiring that, at a minimum, IV diuretics be administered at doses at least 2 times daily PO dose for the first 48 hours after randomization. Since there are currently no widely recognized or accepted guidelines for diuretic dosing nonetheless for maximal or aggressive diuretic dosing, the exact diuretic dosing was left to the discretion of the investigator. Aggressive diureses is supported by the fact that 43% of patients in the UNLOAD standard care arm loss more than 4.6 Kg (10.12 lbs) and this is higher than nearly 80% of patients documented in the Adhere Registry.
