Did the committee consider the hygiene hypothesis as a possible mechanism by which multiple immunizations can make infants susceptible to immune dysfunction?
Yes. The hygiene hypothesis suggests that our immune systems are weaker today than they were in the past because we live in cleaner environments and our immune systems are not strengthened by early exposure to germs. The committees report points out that the potential role of vaccine-preventable diseases as part of this model is minimal (the number of infections prevented by immunization is actually quite small compared with the number prevented by other interventions such as clean water, food, and living conditions). The committee concluded that this mechanism is only theoretical and if proven immunizations would play an insignificant role.
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