Did quality of life differ for women who received IP administration versus IV administration?
In GOG-172, patients in the IP arm reported worse health-related quality of life from the beginning of treatment through its completion; however, one year after the completion of treatment, health-related quality-of-life and pain measures were similar between the two treatment groups, except for paresthesias, or sensations when the abdomen is touched. Paresthesias were more likely to continue at moderate levels among patients on the IP/IV arm. These findings suggest that the additional toxicity, with the exception of paresthesias that may be observed with IP delivery, is generally not a long-term issue for most patients. 13. Why is IP administration not routinely used in the United States, even though it has been practiced for many decades? IP chemotherapy has not been adopted into standard practice across the United States, despite the previous publication of results from seven studies in leading journals, a lead editorial in the Journal of Clinical Oncology, and numerous review artic
