Did ibandronate show a hip fracture reduction in any of its studies?
QuickConsult: Ibandronate did not reveal a hip fracture reduction in any of its studies, as none of the studies with ibandronate were powered to look at hip fracture reduction. The BONE study was powered to provide evidence that there would be a reduction in vertebral fractures, which is the FDA requirement, and ibandronate did reduce vertebral fractures. However, in a post-hoc analysis of the BONE study, it was found that in patients with a T-score of -3 or greater (i.e. – 3.5, -4.0, etc), which represents a higher risk population, there was a 69% reduction in non-vertebral fractures. Ibandronate does not carry an indication for reduction of non-vertebral hip fracture.
