Did ALLHAT results suggest any ethnic or racial differences that might affect prescribing practices?
There are three things to consider regarding ethnic or racial differences in ALLHAT: (1) blood pressure response, (2) events, and (3) side effects. Blood Pressure Response The mean systolic blood pressure was 4mm Hg higher in blacks and 2 mm Hg higher in non-blacks in the lisinopril group than in the chlorthalidone group. Blood pressure control was 8-13% better in the chlorthalidone group than in the lisinopril group for blacks. Although in the trial overall the chlorthalidone group was better controlled than the lisinopril group, this difference between the two groups among blacks is quite striking. Events Chlorthalidone was superior to lisinopril in preventing aggregate cardiovascular events, including stroke, heart failure, angina and coronary revascularization in the trial overall. Stroke and cardiovascular disease outcomes showed some racial differences between the lisinopril and chlorthalidone groups. Black participants assigned to lisinopril had a significantly higher rate of st
