Could It Be a Novel Target for Neurogenic Hypertension?
From the Department of Physiology and Functional Genomics (A.J.F., M.K.R.), College of Medicine, University of Florida, Gainesville; and the Department of Morphology (A.J.F.), Biological Sciences Institute, Federal University of Minas Gerais, Belo Horizonte, Brazil. Correspondence to Mohan K Raizada, Department of Physiology and Functional Genomics, College of Medicine, University of Florida, PO Box 100274, Gainesville, FL 32610. E-mail mraizada{at}phys.med.ufl.edu’ + u + ‘@’ + d + ”//–> Several decades of investigation have provided unequivocal support for the existence of an intrinsic brain renin-angiotensin (Ang) system (RAS) and its involvement in the control of cardiovascular functions.1,2 Essential components of the RAS, ie, renin, angiotensinogen, Ang-converting enzyme, Ang-converting enzyme 2, type 1 Ang II, and type 2 Ang II receptors, as well as various aminopeptidases, are synthesized within the brain, and the hyperactivity of RAS in the brain is implicated in the developm
