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Could infectious prions be distributed in a range of body tissues?

April 26, 2017body distributed prions range tissues

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Could infectious prions be distributed in a range of body tissues?

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Cunningham et al. 2004. Distribution of Bovine Spongiform Encephalopathy in Greater Kudu. Emerging Infectious Diseases www.cdc.gov/eid Vol. 10, No. 6, June 2004. Contrary to findings in cattle with BSE in which the tissue distribution of infectivity is the most limited recorded for any of the transmissible spongiform encephalopathies (TSE), infectivity in greater kudu (Tragelaphus strepsiceros) with BSE is distributed in as wide a range of tissues as occurs in any TSE. BSE agent was also detected in skin, conjunctiva, and salivary gland, tissues in which infectivity has not previously been reported in any naturally occurring TSE. The distribution of infectivity in greater kudu with BSE suggests possible routes for transmission of the disease and highlights the need for further research into the distribution of TSE infectious agents in other host species.