Could doxorubicin been administered as a daily bolus at the time point 1, 24, 48 hours instead of the 48-hour continuous infusion stated in the protocol?
There is increasing evidence that the mode of administration plays an important role for doxorubicin-induced cardiotoxicity and data indicate that bolus administration rather than continuous infusion appears to be an important risk factor. In EURAMOS 1 it is mandatory to give doxorubicin as a 48 hour continuous iv infusion and therefore all patients should have a central line.
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