Could anyone plzzz describe the control of the cell cycle in cancer?
The no. of cells in your body is near constant.cell growth replaces cells, while apoptosis eliminates damaged celss without causing inflammation. If a cells DNA is damaged, there are DNA repair mechanisms but by and large they’re useless and so the body kills off the cell by apoptosis and a neighbouring cell divides to replace it. If a cell undergoes mutation (=evolution) it may gain an ability to enter the cell cycle without the need for a growth factor. That cell may also lose the ability to be apoptosed. Hence you have a neoplasm. If the cell can achieve independence from its anchorage in the tissue matrix it can spread via blood vessels or simply drop from one oragn to the next in your peritoneal cavity. As the primary tumor grows it tends to die off in the middle due to lack of blood supplies. Eventually, some cells evolve angiogenesis, the ability to build new blood vessels to the tumor and growth proceeds ( evolution-survival of the fittest cells) Chemotherapy generally works by
