Clomipramine and selegiline: do they influence impulse control?
Author(s): Bert B, Harms S, Langen B, Fink H Affiliation(s): Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universitat Berlin, Berlin, Germany. bert.bettina@vetmed.fu-berlin.de Publication date & source: 2006-02, J Vet Pharmacol Ther., 29(1):41-7. Publication type: Anxiety disorders in dogs are often accompanied by loss of impulse control and can result in inappropriate behaviour such as destructiveness, excessive barking and aggression. The reduction of these undesirable actions is the focus of behaviour therapy. Clomipramine and selegiline have been approved for the treatment of separation anxiety in dogs, but there are anecdotal reports that they produce inconsistent therapeutic effect. Hence, the aim of this study was to verify the efficacy of clomipramine and selegiline for regulating impulse control by using a rat model based on the delay of reward procedure. The principle is that the animal has to decide between an immediate small food reward, no
