Clinical Interpretation FAQs Do all invasive fungal infections result in high serum levels of (1→3)-β-D-glucan?
No. The vast majority of fungi produce (1→3)-β-D-glucan. However, a few fungal genera produce little or no (1→3)-β-D-glucan. These include Cryptococcus, which yields low levels of serum (1→3)-β-D-glucan and the Zygomycetes (Rhizopus, Mucor, Cunninghamella, Absidia, etc.). A negative result does not rule out the presence of one of these genera. The Fungitell assay is indicated for presumptive diagnosis of fungal infection. It should be used in conjunction with other diagnostic procedures, such as microbiological culture, histological examination of biopsy samples and radiological examination.
