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Children with congenital hypothyroidism and their siblings: do they really differ?

April 26, 2017children congenital differ Hypothyroidism siblings

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Children with congenital hypothyroidism and their siblings: do they really differ?

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Rovet JF Department of Pediatrics, Brain and Behavior Program, Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada. joanne.rovet@sickkids.ca OBJECTIVE: Although favorable outcome is typically described in follow-up studies of children with congenital hypothyroidism (CH) identified by newborn screening, IQ reductions and persistent cognitive deficits are still reported. These findings are accounted for by disease and treatment variables as well as methodologic factors including choice of comparison group. Although siblings are ideal because they control for genetic and environmental influences, by definition they have different ages when tested, which can also introduce bias. Because we followed children with CH and their siblings over an extended period of time, there were a number of occasions when both groups were tested at the same age. The purpose of this study was to compare the results of children with CH and their unaffected sib