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CDI seems to be a strong genetic factor in my family (mother, sister, myself, three of my children, my mothers father and her brother). * How high is the possibility that my children will pass on CDI to their children?

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CDI seems to be a strong genetic factor in my family (mother, sister, myself, three of my children, my mothers father and her brother). * How high is the possibility that my children will pass on CDI to their children?

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It sounds as though you have the autosomal dominant form of familial pituitary DI (adFPDI). If so, your affected children have a 50-50 chance of passing the disease to each of their children. If the genetic mutation responsible for the adFPDI in your family has not already been determined, you should have genetic analysis performed because the information will enable your children to have their children tested at birth (or even before) to find out if they will also get CDI.

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