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Case Study: Does a drug prevent cardiomegaly in heart failure?

April 26, 2017cardiomegaly Case drug failure heart study

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Case Study: Does a drug prevent cardiomegaly in heart failure?

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Case-study problem One consequence of heart failure is that the heart gets larger (cardiomegaly). This is a physiological adaptation to allow the heart to pump enough blood to perfuse the organs. Eventually the heart grows so large it is not able to pump blood efficiently. Therefore it makes sense to seek a drug that would reduce cardiomegaly in heart failure. This study tested such a drug in an animal model of heart failure. Half the rats were given the surgery to create heart failure, and half were given sham surgery. In each of those groups, half of the rats were injected with an experimental drug and half were injected with vehicle as a control. (The data are real, but the investigators prefer to remain anonymous).