Can ZOOM deal with 454 data or Helico data?
Answer. ZOOM is optimized for Illumina/Solexa and ABI SOLiD data. ZOOM can get good mapping results on these two instruments. However, the sequencing error types of 454 instrument and Helico instrument are quite different, which contain much short indels. ZOOM can’t guarantee good mapping results because currently ZOOM can only handle one gap of any length rather than many gaps. However, you could give it a try since ZOOM can handle reads over 200bp and can deal with reads of variable lengths automatically. Any feedback would be appreciated. We look forward to supporting these two instruments in the future.
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