Can you perform enzyme inhibition studies using non-P450 enzymes or microsomes from other tissues?
Yes, we can work with you to design a protocol that incorporates UGT and other non-CYP450 enzymes, or examine CYP450 inhibition in non-hepatic tissues such as lung or intestinal microsomes. We can also perform inhibition studies in other species, which may help determine the appropriate in vivo model or explain results observed in the clinic.
