Can we justify spermatid microinjection for severe male factor infertility?
I Aslam, Simon Fishel0, S Green, A Campbell, L Garratt, H McDermott, K Dowell and S Thornton CARE Centres for Assisted Reproduction, The Park Hospital, Sherwood Lodge Drive, Burntstump Country Park, Arnold, Nottingham, NG5 8RX. UK 0 Corresponding author Abstract During 1995 and 1996 the first spermatid pregnancies were announced with both round spermatid ROSI) and elongated spermatid ELSI) injections. These publications were flanked by live births from ROSI in a number of animal species, with resulting offspring appearing normal, healthy and fertile. However, the live births in humans heralded a scientific and ethical debate on the clinical use of this technology; and in a number of countries nationwide moratoria prohibiting spermatid microinjection were enjoined. Concerns surrounded the biological condition of spermatids and clinical implications of utilizing an immature spermatozoan for conception. Nevertheless, case reports and a few scientific studies on human spermatid conception
