Can they be used to treat hematopoietic malignancies?
Bret M. Schipper, MD, Kacey G. Marra, PhD, Albert Donnenberg, PhD, Vera Donnenberg, PhD, Adriana Zeevi, PhD, Urvasti Surti, PhD, Mounzer Agha, MD, J Peter Rubin, MD. University of Pittsburgh, Pittsburgh, PA, USA. Purpose: Many similarities between adipose derived stem cells (ASC’s) and bone marrow derived stem cells have been described in the literature. Importantly, both sources can give rise to hematopoietic cells. This study aims to determine if migratory bone marrow stem cells repopulate the adipose stem cell pool, or if these stem cell pools exist in two separate compartments. If the latter is true, then autogenous ASC’s might be free of the genetic mutations found in hematopoietic malignancies and possibly be used in place of allogeneic bone marrow transplant. To answer this question we examined tissue specimens from patients with two disease states: 1)Chronic Myeloid Leukemia (CML), and 2) history of bone marrow transplant (BMT). Methods: Adipose biopsies and blood samples were
