Can the transplantation of purified stem cells support the regeneration of pancreatic beta-cell function during diabetes?
Diabetes involves a progressive loss of insulin-secreting beta cells within islets of Langerhans, and affects >250 million individuals worldwide. Islet transplantation can establish insulin-independence in severe diabetics, but critical shortages of donor tissue limits its widespread availability. However, regenerative therapies for diabetes are not limited to direct replacement of beta cells. We have established that bone marrow mesenchymal stem cells (MSC) recruit to damaged islets, induce proliferation of host beta cells, and enhance insulin secretion and glycemic control. We intend to identity how MSC impact beta cell regeneration, a critical step towards the development of successful cellular therapies for diabetes. What are the mechanisms by which distinct stem cell subsets co-ordinate complex biological processes such as tissue regeneration? Although our research program focuses on the regeneration of blood vessels and beta cells to treat the complications of diabetes, the proce
