Can the Toolbox take into account mechanisms or modes of action of toxicity?
Yes. The Toolbox contains “mechanistic profilers” which can identify mechanisms or modes of actions relevant for different regulatory endpoints for a target chemical or a list of target chemicals. The user can then search for chemicals having the same mechanisms or modes of action to build chemical categories. Guidance on using these “mechanistic profilers” can be found either in the Guidance Document for Using the OECD (Q)SAR Application Toolbox to Develop Chemical Categories According to the OECD Guidance on Grouping of Chemicals, or among the published training material for the Toolbox.
