Can the Ph.D. libraries be used for in vivo screening?
An exciting recent development is the use of phage display to select organ-specific peptides in vivo. Peptides selected in this manner have been successfully used to specifically deliver drugs to tumor cells. • Pasqualini, R. and Ruoslahti, E. (1996). Organ targeting in vivo using phage display peptide libraries. Nature 380, 364-366. • Arap, W., Pasqualini. R. and Ruoslahti, E. (1998) Cancer treatment by targeted drug delivery to tumor vasculature in a mouse model. Science 279, 377-380. • Chen et al. (2006) Transdermal protein delivery by coadministered peptide identified via phage display. Nat. Biotech.24, 455-460.
