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Can the metabolic syndrome identify children with insulin resistance?

April 26, 2017children identify insulin metabolic resistance SYNDROME

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Can the metabolic syndrome identify children with insulin resistance?

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Hirschler V; Calcagno ML; Aranda C; Maccallini G; Jadzinsky M Nutrition Department, Durand Hospital, Buenos Aires, Argentina. vhirschler@intramed.net OBJECTIVE: The metabolic syndrome is associated with insulin resistance in adults. We defined pediatric metabolic syndrome using criteria analogous to Adult Treatment Panel III. The purpose of this study was to determine whether these criteria are reliable for insulin resistance in children. RESEARCH DESIGN AND METHODS: Out of 167 children (6.7 +/- 3 yr), 73 overweight [body mass index (BMI) > 95 percentile], 41 at risk of overweight (BMI > 85 75 percentile 53.2% (95% CI 45.73-60.86%) and low high-density lipoprotein 27.5% (95% CI 20.77-34.32%) were common in this sample. Compared with patients without any component of the metabolic syndrome, homeostasis model assessment insulin resistance (HOMA-IR) for patients with one through four components was higher (beta = 0.6, 95% CI 0.4-0.