Can the iSCSI set of IP addresses and the LAN set of IP addresses be in a different subnet?
Yes. For a single or multiple servers this is not a problem or restriction. If more than one server is installed, it is recommended that the different subnets defined for the iSCSI set of IP addresses and the LAN set of IP addresses be used across all of the different servers so that all servers configured can be used in a Hot Spare scenario. Please note that Hot Sparing servers requires that the servers be of the same machine type and model as well as hardware installed on those servers.