Can the estimating equations for GFR be used in acute kidney injury (acute renal failure)?
GFR estimates are less accurate in the non-steady state (see question 27); however, serum creatinine can provide important information about the level of kidney function even when it is not in a steady state. Estimated GFR overestimates measured GFR when serum creatinine is rising, and underestimates measured GFR when serum creatinine is falling. In general, if the serum creatinine doubles within one day then the GFR is near zero.
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