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Can the ability of a viral variant to pass from human to human be predicted from its nucleic acid sequence?

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Can the ability of a viral variant to pass from human to human be predicted from its nucleic acid sequence?

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This may be possible in the future and progress is being made in identifying conserved amino acid sequences associated with past pandemics [5] but we don’t yet know enough about what determines infectivity and virulence to predict the key correlates of transmissibility just from the viral RNA sequence.

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