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Can terbutaline be used as a nebuliser instead of intravenous injection for inhibition of uterine activity?

April 26, 2017activity inhibition injection Intravenous nebuliser terbutaline Used uterine

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Can terbutaline be used as a nebuliser instead of intravenous injection for inhibition of uterine activity?

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Terbutaline, a betamimetic drug, is used as bolus of 0.25 mg intravenously to inhibit uterine activity when encountered with uterine hyperstimulation and associated fetal heart rate changes. The effect of terbutaline used as a nebuliser in 1- and 2-mg doses on uterine activity in labor was investigated. It did not show any significant inhibition of the uterine activity in spontaneous term labor. Although convenient and easy to administer especially in an emergency, 1 or 2 mg terbutaline used in the form of nebuliser did not give the desired effect like 0.25 mg of terbutaline given intravenously for inhibition of uterine activity in term labor.