Can spot urine protein/creatinine ratio replace 24 h urine protein in usual clinical nephrology?
Lane C; Brown M; Dunsmuir W; Kelly J; Mangos G Department of Medicine, St George Clinical School, University of New South Wales, Australia. BACKGROUND: This prospective study was designed to assess whether a single urine specimen, collected at the time of clinical assessment, could be used to estimate 24 h urinary protein excretion. METHODS: The spot urinary protein/creatinine ratio (P/Cr) and 24 h urine protein and creatinine excretion were determined from 103 patients attending a nephrology clinic. Using the spot urine P/Cr, a regression equation was derived, predicting 24 h protein excretion. The performance of the regression equation was tested on a new cohort of 85 patients. Within this new cohort, agreement between the predicted and the actual 24 h urinary protein excretion was assessed using the Bland-Altman technique. The ability of spot urine P/Cr and dipstick urinalysis to predict different threshold levels of protein excretion was assessed using a series of receiver operator
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