Can social adaptation be a determinant factor?
Objective: Major depression is a frequent disorder successfully treated with antidepressants (1). Response and remission depend on the type of pharmacological treatment as well as patient characteristics. The aim of the study is to evaluate the factors influencing response and remission rates. Method: Data from 4 studies (2-4) sharing the same methodology is pooled and reanalyzed. Subjects with major depression were assigned to reboxetine, sertraline or venlafaxine XR treatment in an open label fashion. The initial dose of reboxetine and venlafaxine XR were 4mg/day and 75mg/day respectively. The dose was increased at the second week to 8mg/day for reboxetine and 150mg/day for venlafaxine XR. Sertraline dose was 50mg/day throughout the study. Subjects were assessed at baseline, 2 weeks, 4 weeks, 7 weeks and 10 weeks with Hamilton Depression Rating Scale (HDRS) (5), Hamilton Anxiety Rating Scale (HARS) (6) and, Social Adaptation Self-Evaluation Scale (SASS) (7). Results: Characteristics
