Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?
OBJECTIVE: To evaluate the role of apolipoprotein C-I (apoC-I) levels and assess relationships between apoC-I and clinical features in women with polycystic ovary syndrome (PCOS). DESIGN: Prospective study. SETTING: Reproductive Center of Peking University Third Hospital. PATIENT(S): Thirty patients with PCOS with insulin resistance, 30 patients with PCOS without insulin resistance, and 30 control individuals. INTERVENTION(S): Fasting serum samples. MAIN OUTCOME MEASURE(S): Measures of serum apoC-I, androgens, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoA1, apoB, heat-shock C-reactive protein, glucose, and homeostasis model assessment of insulin resistance (HOMA-IR). RESULT(S): We found differentially expressed proteins by use of the surface-enhanced laser adsorption/ionization (SELDI) protein chip in the serum of women with PCOS and controls. Of these, apoC-I, was highly up-regulated. ApoC-I is associated with glycome
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