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Can serum and urine be used interchangeably to monitor smoking cessation efforts?

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Can serum and urine be used interchangeably to monitor smoking cessation efforts?

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Since cotinine levels in urine are approximately 10 times higher than those is serum, both types of specimens can be used interchangeably as long as the practitioner remembers to account for the concentration in urine. However, if serial monitoring is desired, it is preferable to utilize only one specimen type.

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