Can SAM-e be used with prescription antidepressants or joint remedies?
Since SAM-e has shown no negative interactions, it is safe to use with other products. In fact, because of its rapid effects, many practitioners recommend it to patients to speed the onset of prescription antidepressants. SAM-e is also often recommended when patients are experiencing prescription antidepressant fade-out or when prescription side effects are unacceptable.