Can problems in redox lead to disease?
Yes. At its core a redox “problem” would be expected to result in inadvertent oxidation of an untoward substrate leading, to what is often refereed to as oxidative stress. While oxidative stress events have been observed in a wide variety of disease of aging ranging form diabetes, cardiovascular disease, cancer and neurodegenerative disease, it has become increasing clear that discrete alterations in redox reactions play a far greater role in disease. A convincing body of data is emerging suggesting that defects in redox signaling pathways can trigger inflammation, autophagy, programmed cell death, and other disease-associated mechanisms.
