Can Perinatal Supplementation of Long-Chain Polyunsaturated Fatty Acids Prevent Hypertension in Adult Life?
EFA Sciences LLC, Norwood, Mass. Correspondence to Dr Undurti N. Das, MD, FAMS, EFA Sciences LLC, 1420 Providence Hwy, Suite 266, Norwood, MA 02062. E-mail undurti{at}hotmail.com’ + u + ‘@’ + d + ”//–> Abstract Abstract It is suggested that adequate provision of long-chain polyunsaturated fatty acids during the critical periods of brain growth prevents the development of hypertension in later life. Key Words: fatty acids docosahexaenoic acid breast-feeding tumor necrosis factor insulin resistance hypertension Stimuli or insults induced during the perinatal period can have lifetime consequences and are called programming. Programming stimuli may be generated endogenously (eg, hormonal signals), or they may be environmental. Early nutrition is an important environmental signal that can induce lifetime effects on metabolism, growth, and neurodevelopment and on major disease processes such as hypertension, diabetes mellitus, and obesity. Barker et al1 reported that small size at birth or
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