Can ParaView stream my data sets (process them out-of-core) ?
VTK has some useful streaming features that allow you to process a large data set without ever having to load the entire data set into memory. ParaView has not yet been set up to take advantage of this VTK feature. I would suggest creating a visualization in ParaView using a smaller/lower resolution data set. You could then save out the pipeline into a Tcl script, add a streaming filter and use VTK to process the large data set.