Can one neuron release more than one neurotransmitter? Why is it comforting to discuss problems with others?
Can one neuron release more than one neurotransmitter? —Marvin Shrewsbury, Wailuku, Hawaii Rebecca Seal, a neuroscientist at the University of California, San Francisco, replies: When discussing neurotransmitters, most people think of the classical neurotransmitters, such as dopamine and serotonin—the primary chemical messengers used by neurons to communicate with one another and with other types of cells. In the early 20th century physiologist Sir Henry Dale hypothesized that an individual neuron releases the same classical neurotransmitter from all its axons, the spindly branches that jut out from the main cell body. Another prominent scientist of the time, Sir John Eccles, restated Dale’s principle to also mean that a neuron releases only one neurotransmitter. From that point on, the concept of “one neuron, one transmitter” became widely accepted. Neuroscientists now know, however, that it is common for neurons to release a classical transmitter with another type of messenger, such
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