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Can olanzapine be implicated in causing serotonin syndrome?

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Can olanzapine be implicated in causing serotonin syndrome?

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Haslett CD; Kumar S Department of Psychiatry, Rotorua Hospital, Rotorua, New Zealand. cdhaslett@paradise.net.nz The present paper describes a case of serotonin syndrome (SS), which developed in a patient with bipolar affective disorder after the addition of olanzapine to her regimen of lithium and citalopram. This appears to be the first report that implicates olanzapine with SS. Clinicians should be aware of the risk of SS when adding atypical antipsychotics, such as olanzapine, to serotonergic agents.

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