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Can Octreotide Be Protective?

April 26, 2017octreotide Protective

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Can Octreotide Be Protective?

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Omer Vedat Unalp1, Unal Aydin1, Pinar Yazici1, Deniz Nart2, Cigdem Yenisey3, Tulay Kavak3, Murat Zeytunlu1, Ahmet Coker1 Departments of 1General Surgery and 2Pathology, Ege University School of Medicine. Izmir, Turkey. 3Department of Biochemistry, Adnan Menderes University School of Medicine. Aydin, Turkey ABSTRACT Objective The aim of this study was to evaluate the negative effects of the Pringle maneuver on pancreatic tissue with respect to the time of performing the maneuver. Moreover, the efficacy of octreotide therapy on pancreatic changes at the time of the Pringle maneuver was assessed. Animals Fifty male Wistar Albino rats were randomized into 5 groups. Design The groups were formed as follows: Group A: sham operation, Group B: Pringle maneuver for 30 min plus octreotide (PM30-OCT), Group C: Pringle maneuver for 60 min plus octreotide (PM60-OCT) and Group D: Pringle maneuver for 30 min plus 0.9 % saline solution (PM30-SS), Pringle maneuver for 60 min plus 0.9 % saline solution