Can nicotine in cigarettes and marijuana interact with each other causing strange mood issues?”
Firstly, THC and nicotine (and addiction in general) can induce strange mood issues on their own since they directly bind to receptors and induce changes in neurons in your brain. Secondly, of more importance is that THC can induce schizophrenia in those that might be genetically predisposed. So if their are any severe mood issues, a doctor should be seen immediately to rule out schizophrenia. Long term THC use by adolescents has also been shown to increase risks of depression and anxiety, and decrease cognitive abilities. There aren’t any known direct interactions because these two drugs effect two different types of neuronal signaling. THC effects the endocannabinoid system, while nicotine mostly effects cholinergic neurons. Co-consumption can lead to other effects (which are mostly behavioral) explained in detail in this scientific review article: Nicotine and cannabinoids: parallels, contrasts and interactions (Viveros et al, 2006) Some of the general findings discussed: • The two
