Can new sequences be appended to an existing database and will they be indexed?
Yes, the rapid append mode (‑a option) of xdformat is available for indexed databases; appends occur only marginally slower when an index is being maintained. Appended sequences will have their identifiers indexed using the same T restrictions (if any) that were specified when the database was first created. Indexing of identifiers occurs automatically and unconditionally during appends to a previously indexed database, without the need to specify the I or X option when appending.