Can microorganisms become resistant against chlorine dioxide?
Chlorine dioxide as a disinfectant has the advantage that it directly reacts with the cell wall of microorganisms. This reaction is not dependent on reaction time or concentration. In contrast to non-oxidizing disinfectants, chlorine dioxide kills microorganisms even when they are inactive. Therefore the chlorine dioxide concentration needed to effectively kill microorganisms is lower than non-oxidizing disinfectant concentrations. Microorganisms cannot built up any resistance against chlorine dioxide.