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Can methotrexate solution be administered orally?

April 26, 2017administered methotrexate orally solution

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Can methotrexate solution be administered orally?

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Methotrexate tablets are available. Oral methotrexate solution is not commercially available. However, in literature some information is given regarding this form of administration. Marshall and Gertner describe an oral formula by diluting injectable methotrexate with distilled water1. No specific information is given. 1) Marschall PS, Gertner E. Oral administration of an easily prepared solution of injectable methotrexate diluted in water: A comparison of serum concentrations vs methotrexate tablets and clinical utility. J Rheumatol. 1996 Mar;23(3):455-8.