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Can Malarone(TM) (Atovaquone/Proguanil) be used with VIVOTIF®?

April 26, 2017atovaquone Malarone proguanil TM Used vivotif®

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Can Malarone(TM) (Atovaquone/Proguanil) be used with VIVOTIF®?

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Malarone(TM) is a combination of Proguanil and Atovaquone. The FDA approved package insert for Vivotif® states that a 10-day period should be observed between the use of Proguanil and Vivotif®. While the original testing was done with Proguanil alone, until the FDA reviews data with the combination product (ie, Malarone(TM)) the 10-day separation of between Vivotif® and Proguanil applies. * Faucher, JF, et al, Efficacy of atrovaquone/proguanil for malaria prophylaxis in children and its effect on the immunogenicity of live oral typhoid and cholera vaccines, Clin Infect Dis 15;35(10):1147-54, Nov 2002. Malarone (TM) is the trademark of GlaxoSmithKline for Atovaquone/Proguanil.