Can leucovorin calcium be used for mouth rinsing (after stomatitis which is caused by methotrexate)?
Leucovorin calcium TEVA is not registered for this indication. Mucositis is one of the major problems encountered after the administration of systemic chemotherapy. In one study, 15 normal human volunteers were given leucovorin calcium mouthwash. The study concluded that a small amount of leucovorin calcium is absorbed systemically when administered as a mouth wash. Such an amount would most likely not be significant enough to reduce the effect of methotrexate therapy, but may reduce mucositis1). 1) Fiore JJ et al. Systemic absorption of a leucovorin mouth wash: a pharmacologic study. Cancer Invest.
