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Can lentivirus pass the blood brain barrier (BBB)?

April 26, 2017barrier BBB blood brain lentivirus pass

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Can lentivirus pass the blood brain barrier (BBB)?

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Given the size of the particles and the current VSV-G pseudotype, it is not expected that lentivirus will pass through the BBB (although we have no data to support this claim). Multiple researchers targeting areas of the brain have shown that direct cranial injection is optimal.